APC gene

Mutations in the APC gene may result in colorectal cancer and desmoid tumors. APC. Available structures.

由 LN Kwong 著作 · 2009 · 被引用 333 次 — Colon cancer closely follows the paradigm of a single “gatekeeper gene.” Mutations inactivating the APC (adenomatous polyposis coli) gene are found in ~80% ...

Several mutations in the APC gene have been found in people with a type of aggressive but noncancerous (benign) growth called a desmoid tumor. These rare tumors ...

2013年3月1日 — The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein ...

In 1997, a Johns Hopkins research team found an inherited genetic mutation called APC I1307K. Adenomatous polyposis coli (APC) is a gene that suppresses ...

由 B Li 著作 · 2023 · 被引用 4 次 — APC (adenomatous polyposis coli) gene mutation is a central initialization in colon cancer tumorigenesis. However, the connection between APC ...

由 W Hankey 著作 · 2018 · 被引用 167 次 — Biallelic mutation of the APC gene occurs in 45%–80% of colorectal cancers [5–7] and is observed in the earliest detectable lesions [2]. The APC locus was ...

2024年2月25日 — FAP and AFAP are caused by mutations in the APC gene. These conditions are rare, occurring in about one in 10,000 people. People with FAP may ...